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It has been found that the ROS-Nrf2-antioxidant response element axis may be accountable for the elevation of SLC7A11, which is considered a potential compensatory mechanism to repress ferroptosis in HH

(8) Furthermore, FOXO4's role in the IIS pathway suggests it might modulate the actions of diet and environmental factors on cell aging, acting as a mediator between external factors and cellular longevity pathways

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Given that amylin signalling is a key therapeutic target for next-generation weight-loss drugs, amylin receptor agonists such as pramlintide, cagrilintide and KBP-066 also warrant consideration as to metabolism and detection strategies in sports drug testing programs